Getting Started With Syde

in Your Clinical Research

The Syde Platform

Syde^® is an end-to-end digital health technology (DHT) platform developed by Sysnav Healthcare for the continuous, real-world assessment of upper and lower limb motor function in clinical studies. It combines wearable sensors, proprietary algorithms, and clinical operations support into a single, GCP-compliant solution.

One of the variables offered by the Syde platform is SV95C (Stride Velocity 95th Centile). Sysnav Healthcare obtained EMA qualification for this metric in 2023, making it the first digital endpoint qualified as a primary endpoint for clinical trials.

The Syde platform is composed of:

Ankle and/or wrist worn wearables with centimetric precision

GCP-compliant clinical operation services

Validated & qualified analytics services

How does the Syde Platform work?

Patients wear lightweight sensors on their wrists and/or ankles during daily activities. Each night, sensors are placed on
a docking station for passive data transfer and charging. Sysnav’s proprietary algorithms then process this data into
clinical variables, ready for investigator review.

In real life, the Syde® sensors continuously record data during the day while the patient wears them.
At night, they are placed on their docking station for battery charging and data uploading.

In our servers, the Syde® algorithms use sensor data to reconstruct 3D trajectories and compute stride-level parameters and Syde®-derived clinical variables.

At the time of study data analysis, the variables are presented to sponsor and clinicians for interpretation.

Potential Value in Your Research

Beyond the EMA-qualified SV95C, the Syde platform offers a wide range of digital variables to meet specific research objectives across various pathologies, depending on the clinical concepts of interest relevant to your study.
Here is a selection of some of our digital endpoints:

Concept of Interest

Digital Endpoint

Ambulatory Capacity

Stride velocity 95^th centile (SV95C)
Stairs climbing velocity
% of running

Balance & Stability

Stance percentage

Gait Quality

Stride length 95^th centile
Median stride length

Fatigue

90^th percentile of walking perimeter
Decline in walking speed over time

For instance:

Researchers at Stanford Medicine utilized the Syde wearable device to evaluate the stride-level kinematics and balance metrics of patients affected by myotonic dystrophy type 1 (DM1).^a
Researchers at the Massachusetts General Hospital (MGH – Harvard University) leveraged Syde to evaluate the ambulatory function and disease progression of patients affected by Amyotrophic Lateral Sclerosis (ALS) in a one-year Natural History Study.^b
Researchers at the University of Oxford deployed the Syde wearable to evaluate the real-world ambulatory function and disability progression of patients affected by Multiple Sclerosis (MS) in a 12-month longitudinal study.^c

a. Ismail, S., et al. (2026). Digital Gait Biomarkers in Myotonic Dystrophy: An Exploratory Pilot of Wearable Kinematics and Clinical Associations During the 6MWT. MDA 2026 Poster.

b. Servais, L., et al. (2026). Wearable Sensor-Derived Digital Outcomes for Quantifying Gait in ALS. MDA 2026 Poster.

c. Servais, L ., et al. (2026). Stride-level measurement of gait as an early sensitive marker of disability progression in ambulatory patients with multiple sclerosis. Research Study (NCT04888689/NCT04882891).

Regulatory Compliance

Sysnav Healthcare upholds the highest standards of quality, security, and regulatory compliance. The Syde platform is GCP-compliant and operates under certified quality and information security management systems to ensure patient data confidentiality and clinical study data integrity. Our quality and security framework includes: